first_imgPolice in Derry are appealing for information about a hit and run incident in which a woman was knocked down at a pedestrian crossing by a Donegal-registered car.The incident happened at Strand Road close to the Centra forecourt in the city around 7.00am on Tuesday last, 15 October 15.The woman told police a black Audi A4 with a DL number plate ran the red lights and knocked her to the ground. Anyone with information about the incident is asked to contact police on 0845 600 8000 or a member of your local Neighbourhood Team directly – details can be found on the PSNI website. Alternatively, if someone would prefer to provide information without giving their details, they can contact the independent charity Crimestoppers and speak to them anonymously on 0800 555 111.  POLICE HUNT DONEGAL REGISTERED CAR AFTER HIT AND RUN was last modified: October 21st, 2013 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Audi A4DerryDonegal registered carStrand Roadlast_img read more

Neitsi ® 14″ Straight Clip in Hair Synthetic Hair Extensions -3 Piece/set- Clip-on Hair Weft : I really love it, will definitely order more for extra thick

first_imgI can’t believe the price of these. They r so thick and blend in really well with my dark brown/black hair, recommend to all first time buyers. I really love it, will definitely order more for extra thick hair. Neitsi® 14″ Straight Clip in Hair Synthetic Hair Extensions -3 Piece/set- Clip-on Hair Weft (#N-Blonde(#530))High Quality Synthetic Clip in Hair, Low Price, Best ServiceLength of 14inch, Condition: Brand new, Total Weight: ±73g, Color: 8 Colors AvailablePacking including: 2clips (width: 4.72inch) *1piece, 3clips (Width: 8.27inch, 8.66inch) *2pcsHarmless To Hair, Soft Touching, Tangel Free, Trendy Design, SpecialtySet Contents: 1×4.72″ Wide With 2 Clips Attached; 2×8.27″ Wide With 3 Clips Attached. These are great specially for the price. Look very natural and they are very thick witch i love as great for blending with short hair you can not. Apply heat to these though as i did and one it melted lol. Or frazzled so it’s better to curl your own hair then put them as they are quiet wavey anyway so blends colour match was perfect for my hair had them in last few days and everyone though my hair just grew so very natural looking :). Not to thin, and the colour was accurate to the picture. Excellent hair quality, black was a little bit too dark for me but it was good enough i love it :). Neitsi® 14″ Straight Clip in Hair Synthetic Hair Extensions -3 Piece/set- Clip-on Hair Weft (#N-Blonde(#530)) : Excellent product, and great value for money, really pleased with purchase. Lovely and soft, can’t tell they are fake hair. Darker and ashier than it appears in the picture. I cannot believe how real it looks for the price and it is an absolutely perfect colour match to my hair . Given the price, and the fact that they are synthetic, i’m very impressed with these. I use them to add volume, not length, and they are perfect for this. They blend well with my dark brown hair and, although they are quite shiny, they look natural once blended in properly. Would not recommend for adding length. The clips are secured well and stay in place. A good technique i have found is to gather a little bit of hair underneath where you intend to place the clip, twist it, apply hair spray, then secured the clip in the twist. This really helps them stay in place. Arrived quickly and no problems with seller. Very good, colour match was great. Good for boosting volume after hair loss. Beautiful day or the price, i bought two packs of light blonde and it looked lovely. Made my granddaughter very happy thanks. Arrived today, really pleased beautifully natural all in all great hair peice,. Brilliant product considering how cheap they are, very very happy. Utterly stunning, really natural, incredible value, delivery and packaging outstanding. You won’t be disappointed please buy without fail. Thick, sleek and a great colour. Easy to put in and look the biz. Lovely quality hair extensions. X i ordered med brown and the colour is what i expected. I have fine/thin hair so will prob need to back comb a little first but im pleased. Arrived quickly and well packaged. SummaryReviewer Nathalie DuboisReview Date2019-04-23 02:03:29Reviewed Item Neitsi® 14″ Straight Clip in Hair Synthetic Hair Extensions -3 Piece/set- Clip-on Hair Weft (#N-Blonde(#530))Rating 5.0 / 5  stars, based on  27  reviews Posted on April 23, 2019Author Nathalie DuboisCategories Hair ExtensionsTags Neitsilast_img read more

It’s Official: Apple is Back in the Enterprise Game

first_imgklint finley Cognitive Automation is the Immediate Future of… Related Posts 3 Areas of Your Business that Need Tech Now Massive Non-Desk Workforce is an Opportunity fo…center_img IT + Project Management: A Love Affair Tags:#enterprise#mobile Today Apple sent out a promotional email titled “Mac in the Enterprise,” marking the company’s official return to the enterprise marketplace. This should come as no surprise to those that read our article on Apple poaching enterprise sales people from RIM. However, Apple’s enterprise strategy has been a mystery for the past couple years. As InfoWorld reports, Apple’s VP of enterprise sales left the company in 2008 and was never replaced. Apple also recently announced it will shut down Xserve at the end of this month.Last summer, Steve Jobs expressed his distaste for the enterprise market:What I love about the consumer market that I always hated about the enterprise market is that we come up with a product, we try to tell everybody about it, and every person votes for themselves. They go yes or no. And if enough of them say yes, we get to come to work tomorrow. You know? That’s how it works. It’s really simple. That’s why in the enterprise market it’s not so simple. The people that use the products don’t decide for themselves. And the people that make those decisions sometimes are confused. We love just trying to make the best product in the world for people, and having them tell us by how they vote with their wallets whether we’re on track or not.However, the iPhone and iPad have been gaining traction in the enterprise, as have Macintosh desktops. Meanwhile, Apple has taken steps to improve enterprise support for iOS. So it’s been clear for some time that Apple hasn’t abandoned the enterprise market altogether.I haven’t seen a copy of Apple’s email yet, so I don’t know the details. InfoWorld reports that it is “chockfull of information for large businesses on how to integrate Macs, iPhones, and iPads into their IT ecosystems.” This, combined with its enterprise sales force, is clear evidence that Apple is back in the enterprise game.With interest in iPads and iPhones, and ever-present concerns about the security of Microsoft Windows, 2011 could be the year that Apple starts making serious gains in the business market.last_img read more

PBA: Rain or Shine bounces back, stuns San Miguel

first_imgPrivate companies step in to help SEA Games hosting Oil plant explodes in Pampanga town Qatar to play in Asian Cup final after UAE protest dismissed PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Sports Related Videospowered by AdSparcRead Next ‘We are too hospitable,’ says Sotto amid SEA Games woes US judge bars Trump’s health insurance rule for immigrants SEA Games hosting troubles anger Duterte Don’t miss out on the latest news and information. Four-time MVP James Yap scored 21 points in a relief role at the shooting guard spot, but the Painters got the biggest boost from rookie Javee Mocon, who had career-highs of 18 points and 16 rebounds that caught the Beermen by surprise.Rain or Shine improved to 3-1 while the four-time defending champion Beermen, who missed Arwind Santos but welcomed Terrence Romeo back, took a rare second straight loss and dropped below .500 for the first time at 2-3.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine ‍football chiefSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption charges PDEA chief backs Robredo in revealing ‘discoveries’ on drug war MOST READ ‘We are too hospitable,’ says Sotto amid SEA Games woes LATEST STORIES ANTIPOLO–Rain or Shine came out with a lot of zest and took the very best that San Miguel Beer could offer on Friday night, carving out a 108-98 victory for a great bounce back from its first loss in the PBA Philippine Cup eliminations at Ynares Center here.The Elasto Painters used a huge second quarter to gain control before fending off several uprisings by the Beermen and get back on track after dropping a 99-111 upset at the hands of Blackwater just a couple of nights agoADVERTISEMENT Grace Poe files bill to protect govt teachers from malicious accusations View commentslast_img read more

Alabama State Troopers are investigating after a m

first_imgAlabama State Troopers are investigating after a man died in a two-vehicle crash Sunday in Brookwood.James William Duncan, 51, was killed when another vehicle driven by Roderick Ramon Armistad, 39, of Hoover struck his. Duncan, who was not wearing a seat belt, was ejected from his vehicle and pronounced dead at the scene.The crash happened at 6:45 p.m. at the intersection of Interstate 59 and Covered Bridge Road.last_img

Weakened metabolism of immune T cells may account for serious complications in

Source:https://hms.harvard.edu/news/graying-t-cells Reviewed by James Ives, M.Psych. (Editor)Dec 14 2018The elderly suffer more serious complications from infections and benefit less from vaccination than the general population. Scientists have long known that a weakened immune system is to blame but the exact mechanisms behind this lagging immunity have remained largely unknown.Now research led by investigators at Harvard Medical School suggests that weakened metabolism of immune T cells may be partly to blame.The findings, published Dec. 10 in PNAS and based on experiments in mouse immune cells, pinpoint a specific metabolic pathway called one-carbon metabolism that is deficient in the aged T cells of rodents. The work also suggests possible ways to restore weakened immune function with the use of small-molecule compounds that boost T cell performance.”We believe our findings may help explain the basic malfunction that drives loss of immune defenses with age,” said senior study author Marcia Haigis, professor of cell biology in the Blavatnik Institute at Harvard Medical School. “If affirmed in further studies, we hope that our findings can set the stage for the development of therapies to improve immune function.”The role of T cells in the immune system is twofold: attacking illness-causing cells like bacteria, viruses and cancer and “remembering” past invaders–the body’s way of ensuring that it can spot a threat and mount a rapid defense during subsequent encounters with the same pathogens. In a healthy person, T cells circulate in the blood and quietly scan the body for threats using proteins on the cell’s surface. If a T cell encounters another cell it deems dangerous, the T cell undergoes activation, a molecular cascade in which it switches from surveillance mode to attack mode. The activated cells then rapidly replicate to build an army and destroy the enemy.First, the researchers looked for overall differences between old and young T cells. They isolated T cells from the spleens of young and old mice and noticed that, in general, older mice had fewer T cells. Next, to gauge the cells’ immune fitness, the researchers activated the T cells by mimicking signals normally turned on by pathogens during infection. The older T cells showed diminished activation and overall function in response to these alarm signals. Specifically, they grew more slowly, secreted fewer immune-signaling molecules and died at a much faster rate than young T cells. The researchers also observed that aged T cells had lower metabolism, consumed less oxygen and broke down sugars less efficiently. They also had smaller than normal mitochondria, the cells’ power-generators that keep them alive.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerLiving with advanced breast cancerResearchers identify gene mutations linked to leukemia in children with Down’s syndromeIt was as if these older immune cells had lost their “appetite” and their ability to process fuel into energy, Haigis and her colleagues observed.To pinpoint the metabolic pathways behind this malfunction, the scientists analyzed all the different proteins in the cells, including those that might be important for coaxing a T cell from dormancy into a fighting state. The team found that the levels of some 150 proteins were lower-than-normal upon activation of the aged T cells, compared with young T cells. About 40 proteins showed higher than normal levels in aged versus young T cells. Many of these proteins have unknown functions, but the researchers found that proteins involved a specific type of metabolism, called one-carbon metabolism, were reduced by nearly 35 percent in aged T cells.One-carbon metabolism comprises a set of chemical reactions that take place in the cell’s mitochondria and the cell cytosol to produce amino acids and nucleotides, the building blocks of proteins and DNA. This process is critical for cellular replication because it supplies the biologic material for building new cells.The team’s previous work had shown that one-carbon metabolism plays a central role in supplying essential biological building blocks for the growing army of T cells during infection. So, the scientists wondered, could adding the products of this pathway to weakened T cells restore their fitness and function?To test this hypothesis, the team added two molecules–formate and glycine, the main products of one-carbon metabolism–whose levels were markedly reduced in aged T cells. Indeed, adding the molecules boosted T cell proliferation and reduced cell death to normal levels.The researchers caution that while encouraging, the effects were observed solely in mouse cells in lab dishes rather than in animals and must be confirmed in further experiments. read more